Understanding how cancer cells make proteins to find new treatments
Mechanisms of regulated translation control in cancer and its therapeutic implications
This research explores how cancer cells create the proteins they need to grow and spread, hoping to find new ways to stop them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11160659 on NIH RePORTER |
What this research studies
Cancer cells are very clever; they take over the body's protein-making machinery to produce specific proteins that help them develop and progress. Our team is working to understand exactly how cancer cells do this, using advanced tools and models. We are looking for specific weaknesses in this process that, when targeted, could kill cancer cells without harming healthy ones. This involves studying how certain proteins interact and testing these ideas in laboratory models, including those derived from patient tumors.
Who could benefit from this research
Good fit: This foundational research is for future patients with various types of cancer who may benefit from new, targeted therapies.
Not a fit: Patients seeking immediate treatment options may not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of entirely new drug targets and treatment strategies for various cancers.
How similar studies have performed: This lab has been a leader in this field, developing novel tools and models that have changed our understanding of cancer's molecular origins.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Ruggero, Davide — University of California, San Francisco
- Study coordinator: Ruggero, Davide
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.