Understanding how cancer cells invade tissues as a group
Deconstructing the collective invasion pack to define Myo10 function
This study is exploring how groups of cancer cells work together to spread tumors, focusing on the differences between the leader cells and the follower cells in these groups, to help us understand how they communicate and move, which could lead to new ways to tackle cancer spread.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10830982 on NIH RePORTER |
What this research studies
This research investigates the process of collective invasion in cancer, where groups of cells move together to spread tumors. Using a technique called Spatiotemporal Cellular & Genomic Analysis (SaGA), researchers isolate and analyze living cells within these invasion packs to understand their communication and behavior. The study focuses on the molecular and genetic differences between leader and follower cells in these groups, particularly looking at how changes in gene expression and DNA methylation influence their invasive capabilities. By identifying key genes like Myo10 that are involved in this process, the research aims to uncover new insights into cancer metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors, particularly those experiencing metastasis.
Not a fit: Patients with non-solid tumors or those not currently facing metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancer metastasis, improving patient outcomes.
How similar studies have performed: Other research has shown promise in understanding cancer cell behavior through similar genomic and molecular analysis techniques, indicating potential for success in this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Marcus, Adam I. — Emory University
- Study coordinator: Marcus, Adam I.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.