Understanding how cancer cells interact with brain tissue during metastasis
Project I: Systems analysis of tumor-stroma interactions in brain metastasis
This study is looking at how cancer cells from breast and lung cancers spread to the brain and set up shop there, using mice and computer tools to figure out how this happens, which could help find better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10911892 on NIH RePORTER |
What this research studies
This research investigates how metastatic cancer cells, particularly from breast and lung cancers, interact with brain tissue to establish themselves. By using advanced computational methods and mouse models, the team aims to identify the mechanisms that allow these cancer cells to colonize the brain. The study focuses on the differences in how various types of cancer cells spread and form colonies in the brain, which could lead to new insights into treatment strategies. Patients' clinical samples will be analyzed to better understand these interactions and their implications for disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with breast or lung cancer who are at risk of developing brain metastasis.
Not a fit: Patients with cancers that do not metastasize to the brain or those without a current diagnosis of breast or lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that prevent or treat brain metastasis in cancer patients.
How similar studies have performed: Previous research has shown promising results in understanding tumor-stroma interactions, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Massague, Joan — Sloan-Kettering Inst Can Research
- Study coordinator: Massague, Joan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.