Understanding how cancer cells interact in their environment using advanced technology
Official title: Informing mechanistic rules of agent-based models with single-cell multi-omics
Funded at Trustees of Indiana University · NIH-10990214 · Data updated 2026-11-12
This study is looking at how different cancer cells interact with the tissues around them to find out how these interactions influence treatment outcomes, with the goal of developing better, personalized therapies for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $811,500 |
| NIH project number | 1U24CA284156-01A1 |
| Project ID | NIH-10990214 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are undergoing treatment and can provide tissue samples for analysis.
✕Less likely to help
Patients with non-cancerous conditions or those who are not undergoing any cancer treatment may not benefit from this research.
What this research studies
This research investigates the interactions between different types of cancer cells and their surrounding tissue to better understand how these interactions affect treatment responses. By utilizing cutting-edge single-cell and spatial transcriptomic technologies, the project aims to map cancer tissues and analyze the diverse cell types present. The researchers will combine bioinformatics tools with mathematical modeling to simulate how cancer cells behave and interact over time, providing insights that could lead to more effective therapies tailored to individual patients.
Why it matters
Potential benefit: If successful, this research could lead to personalized cancer treatments that are more effective by understanding the specific interactions between cancer cells and their environment.
How similar studies have gone: Other research has shown promise in using similar approaches to model cancer interactions, indicating potential for success in this novel application.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Macklin, Paul T — Trustees of Indiana University
- Study coordinator: Macklin, Paul T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.