Understanding how cancer cells grow and respond to treatment
Metabolic Control and Anticancer Mechanism
This study is looking at how a specific pathway in cancer cells helps them grow and how certain approved medications can block this pathway, with the goal of finding better ways to treat cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10880639 on NIH RePORTER |
What this research studies
This research investigates the role of the mTORC1 pathway in cancer growth and metabolism, focusing on how cancer cells rely on this pathway for their uncontrolled growth. The study aims to explore the mechanisms behind the action of FDA-approved mTORC1 inhibitors, specifically how they affect cancer cell metabolism through a long non-coding RNA called NEAT1. By examining these processes, the research seeks to improve the effectiveness of existing cancer treatments and provide insights into new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that exhibit high mTORC1 signaling activity and who may benefit from targeted therapies.
Not a fit: Patients whose cancers do not involve the mTORC1 pathway or those who are not eligible for mTORC1-targeted therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by enhancing our understanding of how to better target the mTORC1 pathway.
How similar studies have performed: Previous research has shown promise in targeting the mTORC1 pathway in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Zheng, Steven — Rutgers Biomedical and Health Sciences
- Study coordinator: Zheng, Steven
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.