Understanding how cancer cells' genomic instability affects immune responses
Official title: Genome Instability Induced Anti-Tumor Immune Responses
Funded at University of Pennsylvania · NIH-11085247 · Data updated 2026-11-12
This study is looking at how damage in cancer cells can alert the immune system to fight tumors better, and it's for anyone interested in new ways to improve cancer treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 8, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,717,973 |
| NIH project number | 5P01CA265794-03 |
| Project ID | NIH-11085247 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with tumors exhibiting genomic instability, which may include various types of cancers.
✕Less likely to help
Patients with stable tumors that do not exhibit genomic instability may not benefit from this research.
What this research studies
This research investigates how genomic instability in cancer cells can trigger immune responses that may help fight tumors. The team will explore how DNA damage and changes in cell structure can be recognized by the immune system as foreign threats. By studying these interactions, the researchers aim to uncover new ways to enhance anti-tumor immunity and improve cancer treatment strategies. The project consists of three interconnected projects that will analyze different aspects of this relationship in both laboratory and live tumor environments.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy strategies that better harness the body's immune system to combat cancer.
How similar studies have gone: Previous research has shown promising results in understanding the immune system's response to genomic instability, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Greenberg, Roger a — University of Pennsylvania
- Study coordinator: Greenberg, Roger a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.