Understanding how cancer cells experience stress during cell division
MAPK-driven kinetochore stress in cancer
['FUNDING_R01'] · FRED HUTCHINSON CANCER CENTER · NIH-11161948
This study looks at how stress during cell division affects glioblastoma, a type of brain tumor, and aims to find weaknesses in the cancer cells that could help develop new treatments by analyzing patient tumor samples.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11161948 on ClinicalTrials.gov |
What this research studies
This research investigates a specific type of stress that occurs in cancer cells during cell division, particularly in glioblastoma, a type of brain tumor. The study focuses on a mechanism called MAPK signaling, which can lead to problems in how chromosomes are separated into new cells. By examining this process, the researchers aim to identify vulnerabilities in cancer cells that could be targeted for new therapies. The research involves analyzing tumor samples from patients to understand how this stress affects cancer progression and treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma or other cancers exhibiting similar MAPK-driven kinetochore stress.
Not a fit: Patients with cancers that do not involve MAPK signaling or kinetochore stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target the vulnerabilities of cancer cells, improving outcomes for patients with glioblastoma.
How similar studies have performed: Other research has shown promising results in targeting similar mechanisms in cancer, suggesting that this approach could be effective.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PADDISON, PATRICK — FRED HUTCHINSON CANCER CENTER
- Study coordinator: PADDISON, PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer research, anti-cancer therapy