Understanding how cancer cells experience stress during cell division
Official title: MAPK-driven kinetochore stress in cancer
Funded at Fred Hutchinson Cancer Center · NIH-11161948 · Data updated 2026-11-12
This study looks at how stress during cell division affects glioblastoma, a type of brain tumor, and aims to find weaknesses in the cancer cells that could help develop new treatments by analyzing patient tumor samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $652,799 |
| NIH project number | 1R01CA295090-01A1 |
| Project ID | NIH-11161948 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma or other cancers exhibiting similar MAPK-driven kinetochore stress.
✕Less likely to help
Patients with cancers that do not involve MAPK signaling or kinetochore stress may not benefit from this research.
What this research studies
This research investigates a specific type of stress that occurs in cancer cells during cell division, particularly in glioblastoma, a type of brain tumor. The study focuses on a mechanism called MAPK signaling, which can lead to problems in how chromosomes are separated into new cells. By examining this process, the researchers aim to identify vulnerabilities in cancer cells that could be targeted for new therapies. The research involves analyzing tumor samples from patients to understand how this stress affects cancer progression and treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target the vulnerabilities of cancer cells, improving outcomes for patients with glioblastoma.
How similar studies have gone: Other research has shown promising results in targeting similar mechanisms in cancer, suggesting that this approach could be effective.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Paddison, Patrick — Fred Hutchinson Cancer Center
- Study coordinator: Paddison, Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.