Understanding how cancer cells disrupt the normal cell cycle
Delineating the dystopian nature of the cell cycle in cancer
['FUNDING_R01'] · ROSWELL PARK CANCER INSTITUTE CORP · NIH-11079464
This study is looking at how cancer cells grow and divide differently than healthy cells, which could help us find new ways to treat cancer and understand why some treatments don't work as well.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROSWELL PARK CANCER INSTITUTE CORP (nih funded) |
| Locations | 1 site (BUFFALO, UNITED STATES) |
| Trial ID | NIH-11079464 on ClinicalTrials.gov |
What this research studies
This research investigates how cancer cells manipulate the cell cycle, which is the process that controls cell growth and division. By examining the roles of specific proteins and signals that drive cell cycle progression, the study aims to uncover the complex mechanisms that allow cancer cells to thrive. The researchers will explore different modes of the cell cycle that are present in tumors, which may differ from the normal linear progression seen in healthy cells. This could lead to identifying new therapeutic targets and understanding why some cancer treatments fail.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with various types of cancer, particularly those whose tumors exhibit atypical cell cycle behaviors.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not exhibit unique cell cycle characteristics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by targeting the unique vulnerabilities of cancer cells.
How similar studies have performed: Other research has shown promise in understanding cancer cell cycle dynamics, but this approach aims to delve deeper into previously unexamined complexities.
Where this research is happening
BUFFALO, UNITED STATES
- ROSWELL PARK CANCER INSTITUTE CORP — BUFFALO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KNUDSEN, ERIK — ROSWELL PARK CANCER INSTITUTE CORP
- Study coordinator: KNUDSEN, ERIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer cell line, cancer cell