Understanding how cancer cells control their division
Determining and targeting mechanisms controlling cancer cell division
This study is looking at how certain proteins help cancer cells grow and divide, with the goal of finding new ways to stop that growth, which could lead to better treatments for patients with cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11046667 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate cancer cell division, focusing on the Cyclin D-Cdk4/6-Rb-E2F pathway, which is crucial for cell cycle progression. By examining how alterations in this pathway contribute to cancer, the research aims to identify potential targets for new therapies. The approach includes studying the interactions between proteins involved in this pathway and how they can be manipulated to inhibit cancer cell growth. Patients may benefit from insights gained that could lead to more effective cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with various types of cancer, particularly those with alterations in the Cyclin D-Cdk4/6-Rb-E2F pathway.
Not a fit: Patients with cancers that do not involve the Cyclin D-Cdk4/6-Rb-E2F pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively control cancer cell growth and improve treatment outcomes.
How similar studies have performed: Previous research has shown success with targeting similar pathways in cancer treatment, indicating a promising approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Skotheim, Jan M — Stanford University
- Study coordinator: Skotheim, Jan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.