Understanding how cancer cells communicate to adapt their metabolism in colorectal cancer
Inter-organellar communication in metabolic reprogramming of colorectal cancer
['FUNDING_OTHER'] · ROCKEFELLER UNIVERSITY · NIH-11221426
This study is looking at how different parts of colorectal cancer cells talk to each other and how that affects their ability to grow and survive, especially when there's not enough oxygen around, with the hope that it will help find new ways to treat cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11221426 on ClinicalTrials.gov |
What this research studies
This research investigates the communication between different organelles in colorectal cancer cells and how this affects their metabolism and survival. By studying the interactions between the endoplasmic reticulum and mitochondria, the researchers aim to uncover how these processes are influenced by the tumor microenvironment, particularly under conditions of low oxygen (hypoxia). The study utilizes advanced imaging techniques and genetic screening to identify key mechanisms that support cancer cell growth and resistance to treatment. Patients may benefit from insights that could lead to new therapeutic strategies targeting these metabolic pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer who may be experiencing treatment resistance or disease progression.
Not a fit: Patients with non-colorectal cancers or those who are not currently undergoing treatment for cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve outcomes for patients with colorectal cancer by targeting metabolic adaptations in cancer cells.
How similar studies have performed: Previous research has shown promising results in understanding metabolic reprogramming in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, BRANDON — ROCKEFELLER UNIVERSITY
- Study coordinator: CHEN, BRANDON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, cancer cell, cancer cell metabolism, Cancer Etiology, cancer in the colon