Understanding how cancer cells change to spread lung cancer
Official title: A pro-metastatic secretory program activated by epithelial-to-mesenchymal transition
Funded at University of Kentucky · NIH-11120828 · Data updated 2026-11-12
This study is looking at how lung cancer cells change and spread in the body, with the goal of finding new ways to stop this process and help improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | March 12, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00CA249048-04 |
| Project ID | NIH-11120828 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lung adenocarcinoma or those at risk of lung cancer metastasis.
✕Less likely to help
Patients with non-cancerous conditions or those with cancers unrelated to lung adenocarcinoma may not benefit from this research.
What this research studies
This research investigates the process of epithelial-to-mesenchymal transition (EMT) in cancer cells, which is crucial for the spread of lung cancer. The team aims to uncover how this transition leads to the secretion of substances that promote cancer metastasis. By studying the molecular mechanisms involved, they hope to identify potential targets for new therapies. The research involves collaboration with experts in cancer biology and utilizes advanced techniques to analyze cancer cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce the spread of lung cancer.
How similar studies have gone: Previous research has shown promising results in understanding EMT and its role in cancer metastasis, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
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University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Xiao, Guan-Yu — University of Kentucky
- Study coordinator: Xiao, Guan-Yu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.