Understanding how cancer cells change states during tumor growth
Instability of Cancer Cell States in Tumor progression (ICCS)
This study is looking at how changes in cancer cells can affect tumor growth, helping doctors understand when a tumor might be stable or getting ready to grow, which could lead to better treatment choices for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10915449 on NIH RePORTER |
What this research studies
This research investigates the instability of cancer cell states, focusing on how these changes can influence tumor progression. By examining the gene regulatory networks within cancer cells, the study aims to identify when a tumor is stable or at risk of growing. The approach involves analyzing single-cell transcriptomes to detect signs of instability in small tumors, which could indicate whether they are dormant or preparing to grow. This research could lead to better predictions about tumor behavior and inform treatment decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with small, early-stage tumors that may be in a dormant state.
Not a fit: Patients with advanced-stage cancers or those who do not have solid tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help identify tumors that are at risk of aggressive growth, allowing for earlier and more targeted interventions.
How similar studies have performed: Previous research has shown promise in understanding cancer cell dynamics, but this specific approach to studying cell state instability is relatively novel.
Where this research is happening
Seattle, United States
- Institute for Systems Biology — Seattle, United States (Active)
Researchers
- Principal investigator: Huang, Sui — Institute for Systems Biology
- Study coordinator: Huang, Sui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.