Understanding how cancer cells change in solid tumors
Definition and perturbation of cell-regulatory heterogeneities in solid tumors
['FUNDING_OTHER'] · UNIVERSITY OF VIRGINIA · NIH-11160787
This work helps us understand how individual cancer cells behave differently within solid tumors, especially in breast cancer, to find better ways to treat them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11160787 on ClinicalTrials.gov |
What this research studies
Cancer cells within a tumor are not all the same; they can change their behavior, which makes treatments difficult. This project aims to develop new ways to observe these individual cancer cell changes directly within tumors. Researchers will look at how breast cancer cells change when a specific protein, ERBB2, becomes active. By understanding these changes, we hope to discover new targets for medicines that can overcome treatment resistance.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but focuses on understanding cancer biology relevant to those with solid tumors, particularly breast cancer.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new insights into why cancer treatments sometimes fail and help develop more effective therapies that target the specific ways cancer cells change.
How similar studies have performed: This project builds upon existing technologies like 10-cell RNA sequencing, which has shown promise in analyzing individual cell behaviors.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, LIXIN — UNIVERSITY OF VIRGINIA
- Study coordinator: WANG, LIXIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancers