Understanding how cancer cells change drug responses in metastatic osteosarcoma
Targeting ERK-AKT-mediated single-cell drug response heterogeneity in metastatic osteosarcoma
This study is looking at how cancer cells in metastatic osteosarcoma can change from being treatable to resistant over time, and it aims to find ways to stop this from happening, which could help improve treatment options for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10912078 on NIH RePORTER |
What this research studies
This research investigates how cancer cells in metastatic osteosarcoma can switch between being sensitive and resistant to drugs over time. By studying the signals from the metastatic environment, the researchers aim to identify ways to prevent these harmful transitions. The approach involves using live-cell imaging techniques to observe single cancer cells and their responses to treatment. This could lead to better strategies for managing drug resistance in patients with metastatic osteosarcoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic osteosarcoma who are undergoing treatment.
Not a fit: Patients with non-metastatic osteosarcoma or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with metastatic osteosarcoma by reducing drug resistance.
How similar studies have performed: Other research has shown promise in understanding drug resistance mechanisms in cancer, making this approach both relevant and potentially impactful.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Davies, Alexander E — Oregon Health & Science University
- Study coordinator: Davies, Alexander E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.