Understanding how cancer cells adapt and resist treatment
Investigating the Role of Cell Plasticity in Malignant Transformation
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11046584
This study is looking at how cancer cells change and become tougher to treat as tumors grow, with the goal of finding new ways to help patients respond better to treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11046584 on ClinicalTrials.gov |
What this research studies
This research investigates how cancer cells change and adapt as tumors progress, which can make them more aggressive and harder to treat. The focus is on understanding the molecular mechanisms that allow these cells to become resistant to targeted therapies, particularly those that inhibit specific proteins involved in cell cycle regulation. By using advanced techniques like CRISPR/Cas9 screening, the research aims to identify new factors that influence cancer progression and treatment resistance. This knowledge could lead to better strategies for overcoming resistance and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with advanced adenocarcinoma or other aggressive cancer types who are facing challenges with current treatment options.
Not a fit: Patients with early-stage cancers or those who are not undergoing targeted therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with advanced cancers by overcoming resistance to current therapies.
How similar studies have performed: Other research has shown promise in understanding cancer cell plasticity and resistance mechanisms, indicating that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAIKOVSKY, ANDREA CHRISTINE — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: CHAIKOVSKY, ANDREA CHRISTINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause