Understanding how cancer affects muscle loss and weight in patients
Project 2 NF-#B regulation in muscle wasting and pancreatic cancer-induced cachexia
This study is looking into why some cancer patients, especially those with pancreatic cancer, lose a lot of weight and how we can find better ways to help them manage this issue, so if you join, you could help us learn more about improving health during treatment.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10898567 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cachexia, a severe weight loss condition often seen in cancer patients, particularly those with pancreatic cancer. The study focuses on the NF-κB signaling pathway, which plays a crucial role in muscle wasting and tumor development. By collaborating with experts in various fields, the research aims to uncover new therapeutic approaches to combat cachexia, which currently has no effective treatment. Patients participating in this research may contribute to the understanding of how to better manage their weight loss and overall health during cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are experiencing significant weight loss and muscle wasting.
Not a fit: Patients with non-cancer-related cachexia or those not experiencing significant weight loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively prevent or treat cachexia in cancer patients, improving their quality of life and treatment outcomes.
How similar studies have performed: While cachexia is a well-known complication of cancer, this specific approach targeting the NF-κB signaling pathway is relatively novel and has not been extensively tested in previous research.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Guttridge, Denis C — Medical University of South Carolina
- Study coordinator: Guttridge, Denis C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.