Understanding how cancer affects genome organization
Official title: Epigenetic mechanisms in oncogenic genome organization
Funded at National Cancer Institute · NIH-10498387 · Data updated 2026-11-12
This study is looking at how certain changes in the way genes are organized in cancer cells, especially the MYC gene, can affect how those genes work, which could help find new ways to treat colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Cancer Institute NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| NIH project number | 1FI2GM146623-01 |
| Project ID | NIH-10498387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer or other malignancies associated with alterations in the MYC gene.
✕Less likely to help
Patients with non-malignant conditions or those without any genetic alterations related to the MYC locus may not benefit from this research.
What this research studies
This research investigates the role of epigenetic mechanisms in the organization of the genome in cancer cells, focusing on the MYC gene locus. By using advanced imaging techniques, the study aims to map the structure of the MYC locus in colorectal cancer cells and understand how its positioning within the nucleus influences gene expression. The researchers will also identify specific epigenetic factors that contribute to changes in genome organization during cancer development. This work could lead to the discovery of new biomarkers and therapeutic targets for cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating various cancers by targeting specific epigenetic changes.
How similar studies have gone: Previous research has shown promising results in understanding genome organization and its implications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
National Cancer Institute
Bethesda, United States Active
Researchers
- Principal investigator: Busby, Theodore — National Cancer Institute
- Study coordinator: Busby, Theodore
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.