Understanding how Campylobacter jejuni causes intestinal infections
Integration of nutrient availability, TCA cycle activity, and colonization factor expression in Campylobacter jejuni
This study is looking at how the bacteria Campylobacter jejuni, which can make people sick from food, manages to live in our intestines and cause inflammation, with a special focus on a protein called HeuR that helps it adapt to our gut environment, so we can find better ways to treat infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11127930 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Campylobacter jejuni, a leading cause of foodborne illness, colonizes the intestines and causes inflammation. The study focuses on how this bacterium senses and adapts to the intestinal environment, particularly through a unique regulator called HeuR. By examining the genetic factors that influence colonization and persistence in the human gut, the research aims to uncover new insights into the infection process and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced gastrointestinal infections or are at risk of infection from contaminated food sources.
Not a fit: Patients who do not have a history of gastrointestinal infections or are not at risk of exposure to Campylobacter jejuni may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive measures for infections caused by Campylobacter jejuni.
How similar studies have performed: While research on other gastrointestinal pathogens has been conducted, the specific mechanisms of Campylobacter jejuni remain less understood, making this approach novel.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Johnson, Jeremiah — University of Iowa
- Study coordinator: Johnson, Jeremiah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.