Understanding how Campylobacter bacteria resist multiple antibiotics
Emerging multidrug resistance mechanisms in Campylobacter
This study is looking at how a common bacteria that causes food poisoning, called Campylobacter jejuni, becomes resistant to antibiotics, which can make it harder to treat infections, and it aims to find ways to improve treatment options for people affected by this bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project ID | NIH-10773106 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Campylobacter jejuni, a significant cause of foodborne illness, develops resistance to various antibiotics. The study focuses on a specific efflux pump, CmeABC, which helps the bacteria expel harmful substances and survive in the presence of antibiotics. By examining both the normal and a newly identified 'super' variant of this pump, the research aims to uncover how these mechanisms contribute to treatment failures in patients. The findings could lead to better strategies for managing infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Campylobacter infections or are at high risk of such infections.
Not a fit: Patients with infections caused by other pathogens unrelated to Campylobacter may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from Campylobacter infections.
How similar studies have performed: Previous research has shown success in understanding antibiotic resistance mechanisms in other bacteria, suggesting that this approach could yield valuable insights.
Where this research is happening
Ames, United States
- Iowa State University — Ames, United States (Active)
Researchers
- Principal investigator: Zhang, Qijing — Iowa State University
- Study coordinator: Zhang, Qijing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.