Understanding how calprotectin affects the effectiveness of certain antibiotics
Calprotectin and Antibiotic Activities at the Infection Interface
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10976503
This study is looking at how a protein called calprotectin might make certain antibiotics, like ampicillin and amoxicillin, less effective during infections, and it hopes to find ways to block this protein to help improve treatment for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10976503 on ClinicalTrials.gov |
What this research studies
This research investigates the role of calprotectin, a protein found in neutrophils, in the effectiveness of β-lactam antibiotics like ampicillin and amoxicillin. The study aims to understand how calprotectin can inactivate these antibiotics during bacterial infections, potentially leading to antibiotic resistance. By using mouse models, researchers will assess the impact of calprotectin on antibiotic efficacy and explore ways to inhibit its activity to improve treatment outcomes. Patients may benefit from insights that could lead to more effective antibiotic therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with bacterial infections that are currently treated with β-lactam antibiotics.
Not a fit: Patients who do not have bacterial infections or are not treated with β-lactam antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved antibiotic treatments for bacterial infections, enhancing patient recovery and reducing antibiotic resistance.
How similar studies have performed: Other research has shown promising results in understanding the role of host proteins in antibiotic efficacy, suggesting that this approach could yield significant insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONLON, BRIAN PATRICK — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: CONLON, BRIAN PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.