Understanding how calprotectin affects the effectiveness of certain antibiotics
Official title: Calprotectin and Antibiotic Activities at the Infection Interface
Funded at Univ of North Carolina Chapel Hill · NIH-10976503 · Data updated 2026-11-12
This study is looking at how a protein called calprotectin might make certain antibiotics, like ampicillin and amoxicillin, less effective during infections, and it hopes to find ways to block this protein to help improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | July 23, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $784,059 |
| NIH project number | 1R01AI179695-01A1 |
| Project ID | NIH-10976503 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with bacterial infections that are currently treated with β-lactam antibiotics.
✕Less likely to help
Patients who do not have bacterial infections or are not treated with β-lactam antibiotics may not benefit from this research.
What this research studies
This research investigates the role of calprotectin, a protein found in neutrophils, in the effectiveness of β-lactam antibiotics like ampicillin and amoxicillin. The study aims to understand how calprotectin can inactivate these antibiotics during bacterial infections, potentially leading to antibiotic resistance. By using mouse models, researchers will assess the impact of calprotectin on antibiotic efficacy and explore ways to inhibit its activity to improve treatment outcomes. Patients may benefit from insights that could lead to more effective antibiotic therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved antibiotic treatments for bacterial infections, enhancing patient recovery and reducing antibiotic resistance.
How similar studies have gone: Other research has shown promising results in understanding the role of host proteins in antibiotic efficacy, suggesting that this approach could yield significant insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Conlon, Brian Patrick — Univ of North Carolina Chapel Hill
- Study coordinator: Conlon, Brian Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.