Understanding how calcium transporter SLC24A4 affects tooth enamel formation
Official title: Unraveling the Regulation of Transcription and Activity of Calcium Transporter SLC24A4 in Enamel Formation
Funded at University of California, San Francisco · NIH-11057366 · Data updated 2026-11-12
This study is looking at how a specific protein helps build strong tooth enamel, which is important for people with enamel problems like amelogenesis imperfecta, to better understand how to improve their dental health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $451,000 |
| NIH project number | 1R21DE033833-01A1 |
| Project ID | NIH-11057366 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with amelogenesis imperfecta or other enamel-related disorders.
✕Less likely to help
Patients without enamel disorders or those who do not have a genetic predisposition to enamel formation issues may not benefit from this research.
What this research studies
This research investigates the role of the calcium transporter SLC24A4 in the formation of tooth enamel, focusing on how it regulates the transport of essential minerals during the maturation of ameloblasts, the cells responsible for enamel development. The study aims to uncover the mechanisms that control the expression of SLC24A4, particularly during the transition stages of ameloblasts. By examining the relationship between SLC24A4 activity and enamel strength, the research seeks to provide insights into enamel disorders like amelogenesis imperfecta, which can lead to weakened enamel and dental issues.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for enamel disorders, enhancing dental health and quality of life for affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and molecular basis of enamel formation, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Zhang, Yan — University of California, San Francisco
- Study coordinator: Zhang, Yan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.