Understanding how calcium signals control brain activity
Alpha2delta-mediated control of neuronal signaling
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11034098
This study is looking at how calcium signals in brain cells affect brain activity and could help prevent issues like epilepsy, with the hope that what we learn can lead to better ways to manage or treat related neurological conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11034098 on ClinicalTrials.gov |
What this research studies
This research investigates the role of calcium signals in neurons and how they influence brain activity and excitability. By examining the mechanisms that regulate calcium entry through voltage-gated calcium channels, the study aims to uncover how these signals can prevent dysregulated brain activity, which may lead to conditions like epilepsy. The approach involves exploring the interactions between calcium signals and various proteins within neurons to understand their impact on neuronal firing and communication. Patients may benefit from insights gained into how to better manage or treat neurological disorders linked to calcium signaling.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with epilepsy or autism spectrum disorders who may benefit from advancements in understanding neuronal signaling.
Not a fit: Patients with neurological conditions unrelated to calcium signaling may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neurological disorders, including epilepsy and autism spectrum disorders.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in neurons, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHNELL, ERIC — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: SCHNELL, ERIC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder