Understanding how calcium signals affect insulin release from pancreatic beta cells
Control of beta cell function and survival by RYR2-mediated calcium signals
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10907621
This study is looking at how calcium signals help pancreatic beta cells, which are important for releasing insulin, work and stay healthy, especially when blood sugar levels change, to find new ways to support people with diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10907621 on ClinicalTrials.gov |
What this research studies
This research investigates the role of calcium signals in the function and survival of pancreatic beta cells, which are crucial for insulin release. By using advanced imaging techniques, the study aims to uncover how calcium is released from internal stores within these cells, particularly in response to glucose levels. The researchers will manipulate specific receptors to observe their effects on calcium dynamics and insulin secretion, providing insights into the mechanisms behind diabetes progression. This work could lead to new therapeutic strategies for improving beta cell function in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 1 or type 2 diabetes who are experiencing beta cell dysfunction.
Not a fit: Patients without diabetes or those whose condition is unrelated to beta cell function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetes by enhancing the function of insulin-producing beta cells.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in beta cells, suggesting that this approach could yield valuable insights.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EVANS-MOLINA, CARMELLA — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: EVANS-MOLINA, CARMELLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus