Understanding how calcium signaling works in cells
Molecular basis of the NAADP-gated calcium release channel complexes
This study is looking at how a molecule called NAADP helps control calcium levels in our cells, which is important for many body functions, and it aims to understand how this process works and how it might relate to diseases caused by problems with calcium signaling.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10898852 on NIH RePORTER |
What this research studies
This research investigates the role of nicotinic acid adenine dinucleotide phosphate (NAADP) in calcium signaling within cells, which is crucial for various physiological processes. The study focuses on how NAADP mobilizes calcium from specific cellular compartments and identifies key proteins involved in this signaling pathway. By using advanced techniques like affinity purification and proteomic analysis, the research aims to clarify the molecular mechanisms behind NAADP's action and its implications for diseases linked to calcium signaling defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to calcium signaling abnormalities, such as certain cardiovascular or neurological disorders.
Not a fit: Patients with conditions unrelated to calcium signaling or those who do not exhibit any calcium mobilization issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into calcium-related diseases and potential therapeutic targets.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling pathways, indicating that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Yan, Jiusheng — University of Tx Md Anderson Can Ctr
- Study coordinator: Yan, Jiusheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.