Understanding how calcium signaling affects pancreatic cancer spread
Dissecting the oncogenic and pro-metastatic roles of PTHLH-mediated calcium signaling in pancreatic cancer
This study is looking at how a certain hormone affects the spread of pancreatic cancer in mice, with the goal of finding new ways to detect and treat the disease better for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10897031 on NIH RePORTER |
What this research studies
This research investigates the role of calcium signaling mediated by Parathyroid Hormone Like Hormone (PTHLH) in the progression and spread of pancreatic cancer. Using a mouse model, researchers are examining how the deletion of specific genes influences cancer metastasis and tumor growth. The study aims to identify new therapeutic targets that could improve early detection and treatment options for patients with pancreatic cancer. By exploring the mechanisms of metastasis, the research seeks to provide insights that could lead to better clinical management of this aggressive disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic cancer, particularly those with advanced disease or metastasis.
Not a fit: Patients with early-stage pancreatic cancer or those without metastatic disease may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that significantly improve survival rates for pancreatic cancer patients.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, suggesting that this approach could be beneficial.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Pitarresi, Jason R. — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Pitarresi, Jason R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.