Understanding how calcium signaling affects organ growth and healing
Official title: Regulation and function of multicellular calcium signaling in organ growth and regeneration
Funded at University of Notre Dame · NIH-11011876 · Data updated 2026-11-12
This study is looking at how calcium helps cells talk to each other while organs grow and heal, which could lead to better treatments for conditions like Alzheimer's disease and improve overall cell health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $681,393 |
| NIH project number | 1R35GM156615-01 |
| Project ID | NIH-11011876 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Alzheimer's disease or related conditions that involve impaired calcium signaling.
✕Less likely to help
Patients with conditions unrelated to calcium signaling or organ growth may not receive benefits from this research.
What this research studies
This research investigates the role of calcium ions in cell communication during the development and regeneration of organs. By studying how calcium signaling influences the interactions between different cell types, the research aims to uncover fundamental principles that could lead to improved cellular health and function. The team will utilize advanced techniques to manipulate calcium signaling dynamics, with the goal of correcting disease-related changes in organ size and function. Patients may benefit from insights gained in this research, particularly in conditions like Alzheimer's disease and other related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance organ growth and repair, potentially improving outcomes for patients with diseases like Alzheimer's.
How similar studies have gone: Previous research has shown promising results in understanding calcium signaling dynamics, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: Zartman, Jeremiah James — University of Notre Dame
- Study coordinator: Zartman, Jeremiah James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.