Understanding how calcium signaling affects Calicivirus infection and replication
Calcium signaling in Calicivirus infection and replication
This study is looking at how a virus called Calicivirus affects the way cells handle calcium, which could help the virus spread more easily, and it's aimed at finding new ways to fight this virus.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10847517 on NIH RePORTER |
What this research studies
This research investigates how Calicivirus, a type of enteric virus, disrupts normal cellular processes by altering calcium signaling during infection. The study focuses on the mechanisms by which the virus manipulates calcium levels in infected and neighboring uninfected cells, potentially leading to increased viral replication. By using animal models, researchers aim to characterize these calcium signaling changes and their implications for viral infection. This could provide insights into new antiviral strategies targeting calcium signaling pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently experiencing infections caused by Calicivirus or similar enteric viruses.
Not a fit: Patients with infections caused by viruses other than Calicivirus or those with chronic gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral therapies that target calcium signaling to reduce the impact of Calicivirus infections.
How similar studies have performed: Other research has shown promising results in understanding viral manipulation of cellular processes, indicating that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Scribano, Francesca Jean — Baylor College of Medicine
- Study coordinator: Scribano, Francesca Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.