Understanding how calcium sensors work in nerve cells using a tiny worm.
Investigating the coordinated functions of a dual Ca2+ sensor system in C. elegans
This study is looking at how two special proteins help nerve cells communicate with each other by releasing important chemicals, using tiny worms as a model to learn more about how this works and what it might mean for understanding brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10626684 on NIH RePORTER |
What this research studies
This research investigates the roles of two calcium sensor proteins, synaptotagmin-1 and -7, in the process of neurotransmitter release in nerve cells. By using the model organism C. elegans, which has similar synaptic mechanisms to humans, the study aims to uncover how these proteins coordinate to facilitate communication between nerve cells. The researchers will employ behavioral and electrophysiological techniques to observe the effects of these proteins on synaptic transmission. This approach could provide insights into the fundamental processes that underlie various neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders linked to synaptic transmission defects, such as epilepsy.
Not a fit: Patients with neurological conditions unrelated to synaptic transmission or those without any neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the mechanisms behind neurological disorders, potentially paving the way for new treatments.
How similar studies have performed: Previous studies on synaptotagmin proteins in rodent models have shown promising results, indicating that this approach may yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Richmond, Janet E — University of Illinois at Chicago
- Study coordinator: Richmond, Janet E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.