Understanding how calcium release affects heart rhythm and function
Role of SR-mitochondria interplay in calcium-dependent arrhythmias
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-11248275
This study is looking at how problems with calcium release in heart cells can affect heartbeats, especially for people with genetic conditions like CPVT that can cause irregular heart rhythms, and it hopes to find new ways to help improve heart health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11248275 on ClinicalTrials.gov |
What this research studies
This research investigates the role of calcium release from the sarcoplasmic reticulum in regulating heartbeats, particularly in conditions where this process is disrupted. It focuses on how defects in the ryanodine receptor channel complex can lead to abnormal calcium release, contributing to arrhythmias and heart failure. The study aims to explore the interplay between calcium dynamics and mitochondrial function in heart cells, especially in genetic arrhythmia syndromes like catecholaminergic polymorphic ventricular tachycardia (CPVT). By examining these mechanisms, the research seeks to identify potential therapeutic targets for improving heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with arrhythmias, particularly those diagnosed with catecholaminergic polymorphic ventricular tachycardia or other related cardiac conditions.
Not a fit: Patients with non-cardiac conditions or those without arrhythmias may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with arrhythmias and heart failure by targeting the underlying calcium release mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding calcium dynamics in heart diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, BIN — UNIVERSITY OF FLORIDA
- Study coordinator: LIU, BIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.