Understanding how calcium release affects heart rhythm and function
Official title: Role of SR-mitochondria interplay in calcium-dependent arrhythmias
Funded at University of Florida · NIH-11248275 · Data updated 2026-11-12
This study is looking at how problems with calcium release in heart cells can affect heartbeats, especially for people with genetic conditions like CPVT that can cause irregular heart rhythms, and it hopes to find new ways to help improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 8, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $80,476 |
| NIH project number | 3R01HL166169-02S1 |
| Project ID | NIH-11248275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with arrhythmias, particularly those diagnosed with catecholaminergic polymorphic ventricular tachycardia or other related cardiac conditions.
✕Less likely to help
Patients with non-cardiac conditions or those without arrhythmias may not receive any benefit from this research.
What this research studies
This research investigates the role of calcium release from the sarcoplasmic reticulum in regulating heartbeats, particularly in conditions where this process is disrupted. It focuses on how defects in the ryanodine receptor channel complex can lead to abnormal calcium release, contributing to arrhythmias and heart failure. The study aims to explore the interplay between calcium dynamics and mitochondrial function in heart cells, especially in genetic arrhythmia syndromes like catecholaminergic polymorphic ventricular tachycardia (CPVT). By examining these mechanisms, the research seeks to identify potential therapeutic targets for improving heart health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with arrhythmias and heart failure by targeting the underlying calcium release mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding calcium dynamics in heart diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Liu, Bin — University of Florida
- Study coordinator: Liu, Bin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.