Understanding how calcium levels affect heart muscle function
New mechanisms of SERCA2a regulation: role of luminal calcium
['FUNDING_R01'] · LOYOLA UNIVERSITY CHICAGO · NIH-10766221
This study is looking at how calcium affects a key pump in heart cells that helps your heart relax and contract, with the goal of finding new treatments that could help people with heart failure feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOYOLA UNIVERSITY CHICAGO (nih funded) |
| Locations | 1 site (MAYWOOD, UNITED STATES) |
| Trial ID | NIH-10766221 on ClinicalTrials.gov |
What this research studies
This research investigates the role of calcium in regulating the SERCA2a pump, which is crucial for heart muscle relaxation and contraction. By using advanced techniques such as molecular dynamics simulations and innovative optical methods, the study aims to uncover how changes in calcium levels within heart cells influence the function of SERCA2a. The research will also explore potential therapeutic approaches to improve heart function in patients with heart failure. Patients may benefit from insights gained into new treatments that target SERCA2a regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure or other cardiac dysfunctions.
Not a fit: Patients without any cardiac conditions or those who do not have impaired SERCA2a function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve heart function in patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding calcium regulation in heart function, suggesting that this approach could lead to significant advancements.
Where this research is happening
MAYWOOD, UNITED STATES
- LOYOLA UNIVERSITY CHICAGO — MAYWOOD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZIMA, ALEKSEY V — LOYOLA UNIVERSITY CHICAGO
- Study coordinator: ZIMA, ALEKSEY V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Functional disorder