Understanding how calcium levels affect cell health and disease
Deciphering Molecular Mechanisms of Calcium Homeostasis
['FUNDING_OTHER'] · ALBANY MEDICAL COLLEGE · NIH-10899467
This study is looking at how calcium affects our cells and how problems with calcium can lead to diseases like Alzheimer's, using tiny worms to help us understand how it all works, with the hope that this knowledge could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBANY MEDICAL COLLEGE (nih funded) |
| Locations | 1 site (ALBANY, UNITED STATES) |
| Trial ID | NIH-10899467 on ClinicalTrials.gov |
What this research studies
This research investigates the role of calcium in cellular processes and how its dysregulation can lead to diseases like Alzheimer's. Using the model organism Caenorhabditis elegans, the study aims to uncover the mechanisms that control calcium signaling and its impact on cell function and survival. By examining the function of a protein called presenilin, which is involved in calcium homeostasis, the research seeks to identify critical pathways that could be targeted for therapeutic interventions. Patients may benefit from insights gained about calcium's role in neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those with Alzheimer's disease.
Not a fit: Patients with conditions unrelated to calcium dysregulation or neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases by improving our understanding of calcium signaling.
How similar studies have performed: Previous research has shown that understanding calcium signaling can lead to significant advancements in treating neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
ALBANY, UNITED STATES
- ALBANY MEDICAL COLLEGE — ALBANY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NORMAN, KENNETH R — ALBANY MEDICAL COLLEGE
- Study coordinator: NORMAN, KENNETH R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease