Understanding how calcium channels work in heart cells
Regulation of Cav1.2 Trafficking by GJA1-20k and cBIN1
This study is looking at how certain channels in heart cells help control heartbeats and how they might be affected in heart failure, with the goal of finding new ways to help improve treatments for patients with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10893376 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate L-type calcium channels in heart cells, which are crucial for heart contraction and relaxation. It focuses on how these channels are maintained in specific areas of heart cells called t-tubules, especially in the context of heart failure. By exploring the roles of certain proteins and cellular structures, the research aims to uncover new pathways that could be targeted for developing therapies for heart failure. Patients may benefit from insights gained into the cellular processes that lead to heart dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or related cardiac conditions.
Not a fit: Patients with non-cardiac conditions or those without any heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure by improving our understanding of calcium handling in heart cells.
How similar studies have performed: Other research has shown promise in understanding calcium channel regulation in heart cells, indicating that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Shaw, Robin M — University of Utah
- Study coordinator: Shaw, Robin M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.