Understanding how calcium channels work in cells
Molecular basis of the NAADP-gated calcium release channel complexes
['FUNDING_R01'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-11166651
This research explores how a special signal called NAADP helps control calcium levels inside our cells, which is important for many body functions and may be linked to various diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11166651 on ClinicalTrials.gov |
What this research studies
Calcium is vital for cell functions, and its movement inside cells is carefully controlled. A powerful signal called NAADP helps release calcium from special compartments within cells. Problems with NAADP signaling are connected to many diseases, but we don't fully understand how it works. This project aims to discover the exact molecules involved in NAADP's calcium release, identifying a protein called Lsm12 as a key part of this process. By understanding these molecular details, we hope to learn more about how NAADP affects cell health.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies building on these findings may seek patients with diseases linked to calcium signaling.
Not a fit: Patients not affected by diseases related to calcium signaling disruptions would likely not see direct benefit from this specific basic science project.
Why it matters
Potential benefit: Understanding these basic cellular mechanisms could lead to new ways to treat diseases where calcium signaling is disrupted.
How similar studies have performed: This research aims to uncover novel molecular mechanisms of NAADP signaling, which are currently not well understood.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAN, JIUSHENG — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: YAN, JIUSHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.