Understanding how calcium channels work in cells
Official title: Molecular regulation of the CRAC channel signaling pathway
Funded at University of Cincinnati · NIH-11078865 · Data updated 2026-11-12
This study is looking at how certain proteins work together to control calcium channels in our cells, which are important for many body functions, and it aims to help us understand how these channels behave in both healthy people and those with diseases related to calcium signaling.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 3, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $405,000 |
| NIH project number | 5R35GM151170-03 |
| Project ID | NIH-11078865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to calcium signaling abnormalities, such as certain genetic disorders or diseases affecting cellular communication.
✕Less likely to help
Patients with conditions unrelated to calcium signaling or those who do not have genetic mutations affecting the CRAC channels may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind calcium release-activated calcium (CRAC) channels, which are essential for calcium signaling in various cellular processes. By studying the interactions between specific proteins (Orai and STIM) that regulate these channels, the research aims to uncover how they function in both healthy and diseased states. The approach includes detailed structural and functional studies using model organisms like Drosophila and human cells to gain insights into the role of these channels in different tissues. This knowledge could lead to better understanding of diseases linked to calcium signaling.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to calcium signaling dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding calcium signaling pathways, indicating that this approach has potential for success.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Hou, Xiaowei — University of Cincinnati
- Study coordinator: Hou, Xiaowei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.