Understanding how calcium channels move to nerve endings
Official title: Dissecting the Forward Trafficking of Presynaptic Voltage Gated Calcium Channels
Funded at Harvard Medical School · NIH-11077862 · Data updated 2026-11-12
This study looks at how important channels in nerve cells move to the right spots where they help send signals, aiming to understand the steps they take and the challenges they face along the way, which is important for keeping our brain and nervous system working well.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | April 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $18,040 |
| NIH project number | 5F31NS127399-03 |
| Project ID | NIH-11077862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that may involve dysfunction in synaptic transmission.
✕Less likely to help
Patients with conditions unrelated to synaptic transmission or those not experiencing neurological symptoms may not benefit from this research.
What this research studies
This research investigates the movement of voltage-gated calcium channels, which are crucial for transmitting signals between nerve cells. It focuses on how these channels are transported from their production site in the cell body to their final destination at the presynaptic terminal, where they play a key role in synaptic transmission. The study aims to identify the specific mechanisms and sequences that ensure these channels reach the correct location, which is vital for proper neuronal function. By using advanced techniques, the research will explore the challenges these channels face during their journey and how they overcome them.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of neurological disorders related to synaptic transmission.
How similar studies have gone: Previous research has shown promising results in understanding calcium channel trafficking, indicating that this approach has potential for significant insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Chin, Morven — Harvard Medical School
- Study coordinator: Chin, Morven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.