Understanding how calcium channels in the intestines affect liver damage from alcohol.
Defining the Role of Intestinal Calcium Channels in Alcoholic Liver Damage.
This study is looking at how certain calcium channels in the intestines might play a role in liver damage from drinking alcohol, with the hope of finding new ways to help people with alcohol-related liver issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11043244 on NIH RePORTER |
What this research studies
This research investigates the role of specific calcium channels in the intestines that may contribute to liver damage caused by alcohol consumption. By examining how alcohol disrupts the intestinal barrier and leads to inflammation, the study aims to identify new therapeutic strategies to prevent or treat alcohol-related liver diseases. The researchers will use both clinical data and experimental models to explore the mechanisms behind this process, focusing on the TRPV6 and CaV1.3 calcium channels. The ultimate goal is to develop targeted treatments that can improve outcomes for individuals suffering from alcohol-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have a history of alcohol abuse or alcohol-related liver disorders.
Not a fit: Patients who do not consume alcohol or have no liver-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target intestinal dysfunction to reduce liver damage in individuals who consume alcohol.
How similar studies have performed: Previous research has shown promising results in understanding the role of intestinal barriers in alcohol-related diseases, suggesting that this approach could yield significant insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Rao, Radhakrishna — University of Tennessee Health Sci Ctr
- Study coordinator: Rao, Radhakrishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.