Understanding how calcium channels affect heart health and disease
Mechanisms of L-type Calcium Channel Regulation in Heart Health and Disease
This study is looking at how certain channels in the heart work and how we can improve heart function in people with heart failure, aiming to find safer treatments that help the heart without the side effects of some current medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11096044 on NIH RePORTER |
What this research studies
This research investigates the role of L-type calcium channels in heart function, particularly in the context of heart failure. It aims to find new ways to support heart function without the risks associated with traditional treatments that activate beta-adrenergic receptors. By studying the interactions between a protein called RAD and calcium channels, the researchers hope to develop safer therapies that enhance calcium handling in heart cells. The approach includes both pharmacological and genetic methods to understand these mechanisms better.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or those at risk of developing heart failure.
Not a fit: Patients with non-cardiac conditions or those who do not have any heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer treatments for heart failure that improve heart function without increasing the risk of serious complications.
How similar studies have performed: Other research has shown promise in using alternative pathways to improve heart function, suggesting that this approach could be a valuable advancement in treatment.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Satin, Jonathan — University of Kentucky
- Study coordinator: Satin, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.