Understanding how calcium affects lung cell healing after pneumonia
Official title: Elucidating the contribution of mitochondrial calcium uptake to lung epithelial regeneration
Funded at Temple Univ of the Commonwealth · NIH-11117022 · Data updated 2026-11-12
This study is looking at how lung cells heal after bacterial pneumonia, especially how certain stem cells help with this process, and it aims to find ways to improve lung recovery for older adults and people with ongoing breathing issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 15, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $702,675 |
| NIH project number | 5R01HL172848-02 |
| Project ID | NIH-11117022 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include elderly individuals and patients with chronic respiratory diseases who have experienced bacterial pneumonia.
✕Less likely to help
Patients who are young and healthy, without a history of pneumonia or chronic respiratory issues, may not benefit from this research.
What this research studies
This research investigates how lung cells regenerate after bacterial pneumonia, focusing on the role of specific stem cells called AT2 cells that transform into AT1 cells. It aims to uncover the molecular mechanisms that control this process, particularly how calcium levels influence gene expression and cell differentiation. By examining the activity of certain enzymes that modify histones, the study seeks to identify potential therapeutic targets to enhance lung healing, especially in older adults and those with chronic respiratory conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung regeneration and recovery in patients suffering from pneumonia and related respiratory diseases.
How similar studies have gone: Previous research has shown promising results in understanding cellular differentiation and regeneration processes, suggesting that this approach could yield significant insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Tian, Ying — Temple Univ of the Commonwealth
- Study coordinator: Tian, Ying
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.