Understanding how calcium affects heart function and disease
Modulating mitochondrial calcium in cardiac homeostasis and disease
This study is looking at how calcium in tiny parts of heart cells affects heart health, especially in people with heart failure, to find new ways to help improve heart function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10907781 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial calcium in heart health and disease, particularly focusing on heart failure. By using animal models, the study aims to understand how changes in mitochondrial calcium levels can impact energy production in heart cells. The researchers will manipulate specific genes to either increase or decrease mitochondrial calcium, allowing them to observe the effects on cardiac function. The ultimate goal is to develop therapies that can improve heart function by managing mitochondrial calcium levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure, particularly those with reduced or preserved ejection fraction.
Not a fit: Patients without heart failure or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial function in heart disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Liu, Julia Chang — University of Minnesota
- Study coordinator: Liu, Julia Chang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.