Understanding how calcium affects energy production in cells
Regulation of the mitochondrial calcium uniporter
This study is looking at how calcium affects energy production in heart cells and how too much calcium can cause cell damage, especially during heart attacks, with the hope of finding new treatments to protect the heart.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10857268 on NIH RePORTER |
What this research studies
This research investigates the role of calcium in stimulating energy production within mitochondria, the powerhouses of cells. It focuses on how excessive calcium can lead to cell death, particularly in the heart during conditions like heart attacks. By studying animal models, the research aims to uncover how to better regulate a specific calcium channel known as the mitochondrial calcium uniporter, which is crucial for calcium entry into mitochondria. The goal is to develop targeted therapies that can prevent calcium overload and its harmful effects on heart cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular diseases, particularly those at risk of heart attacks or heart failure.
Not a fit: Patients with non-cardiovascular conditions or those who do not have issues related to calcium overload in their cells may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect heart cells from damage during heart attacks and other cardiovascular diseases.
How similar studies have performed: Previous research has shown promise in using genetic inhibition of the calcium uniporter in animal models, suggesting that this approach may be effective in managing calcium overload.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Chaudhuri, Dipayan — University of Utah
- Study coordinator: Chaudhuri, Dipayan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.