Understanding how calcium-activated channels work in the heart and other tissues
Activation and Inhibition Mechanisms of Calcium-Activated Nonselective Cation Channels
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11083603
This study is looking at specific channels in your cells that help control heart signals, which could be important for people with heart conditions like Brugada syndrome, to find new ways to treat these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11083603 on ClinicalTrials.gov |
What this research studies
This research investigates calcium-activated nonselective cation (CAN) channels, which play a crucial role in converting calcium signaling into changes in membrane potential. The study focuses on the TRPM4 and TRPM5 channels, which have been linked to serious health conditions like Brugada syndrome and cardiac conduction block. By exploring the molecular mechanisms that activate these channels, the research aims to uncover how they function under different conditions. This could lead to the development of new therapies for diseases associated with these channels.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations affecting TRPM4 and TRPM5 channels, particularly those with Brugada syndrome or related cardiac issues.
Not a fit: Patients without any known genetic mutations related to TRPM4 or TRPM5 channels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with heart conditions and other diseases linked to TRPM4 and TRPM5 channels.
How similar studies have performed: Previous research has shown promising results in understanding ion channels, but the specific mechanisms of TRPM4 and TRPM5 channels remain largely untested.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHENG, JIE — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: ZHENG, JIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brugada syndrome