Understanding how C2cd4a affects metabolism and diabetes
Official title: Decipher the Function of C2cd4a in Metabolism
Funded at University of California at Davis · NIH-10987049 · Data updated 2026-11-12
This study is looking at a gene called C2cd4a to see how it affects the insulin-producing cells in the pancreas, which could help us understand better ways to manage type 2 diabetes, especially in relation to exercise and blood sugar levels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $362,250 |
| NIH project number | 5R01DK132227-03 |
| Project ID | NIH-10987049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 2 diabetes or those at risk of developing the condition.
✕Less likely to help
Patients with type 1 diabetes or other forms of diabetes unrelated to insulin resistance may not benefit from this research.
What this research studies
This research investigates the role of the C2cd4a gene in the function of pancreatic beta cells, which are crucial for insulin production. By using a multi-omics approach and functional analysis in mice, the study aims to uncover how C2cd4a influences insulin secretion and its potential link to exercise-induced hypoglycemia. The researchers will explore the mechanisms behind these processes and how they relate to type 2 diabetes treatment. Patients may benefit from insights that could lead to new therapeutic strategies for managing diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for type 2 diabetes by improving our understanding of insulin secretion mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors influencing diabetes, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Kuo, Taiyi Diana — University of California at Davis
- Study coordinator: Kuo, Taiyi Diana
Related research
Other NIH-funded projects on the same topics.
-
UC Davis IGA Innovation Center
A research center at UC Davis will study gene-edited livestock to improve animal health, safety, and policy through sharing genetic data and findings about genome edits in cattle, pigs, sheep, and goats.
-
Administrative Core of an equitable breast cancer screening program
A national program headed from UC Davis is coordinating several research efforts to improve how breast cancer screening is done in community settings.
-
The role of novelty and surprise in learning for people with Alzheimer’s disease
A study explores how surprising events affect memory and learning in people related to Alzheimer’s disease, using everyday tasks to see how the brain remembers new information.
-
Understanding how distraction affects students and how to measure it better
This grant studies why distracted students, including those with ADHD, struggle in real-life learning and tests a clearer way to measure distraction in everyday settings.
-
California Partnership for Personalized Nutrition
A California clinical center is testing personalized dietary approaches to improve blood sugar and health for adults with diabetes by using big data and AI to tailor meals.
-
Advancing gastric cancer care for Latinos through patient-derived tumor models
Aimed at Latinos with gastric cancer, this project uses patient-derived tumor models to study how cancer biology and treatments work in real tumors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.