Understanding how C. difficile spores resist harsh conditions
Impact of the C. difficile small acid soluble proteins on spore physiology
['FUNDING_R01'] · TEXAS A&M UNIVERSITY · NIH-10896214
This study is looking at how certain proteins help Clostridioides difficile spores survive tough conditions, which could lead to better treatments for patients dealing with C. difficile infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-10896214 on ClinicalTrials.gov |
What this research studies
This research investigates the role of small acid soluble proteins (SASPs) in the resistance of Clostridioides difficile spores to environmental stressors. By analyzing how these proteins interact with DNA and contribute to spore formation, the study aims to uncover mechanisms that allow C. difficile to survive in hospital settings. The research involves creating mutant strains of the bacteria to observe changes in spore physiology and resistance. Patients may benefit from improved understanding of C. difficile infections and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced recurrent C. difficile infections or are at high risk for such infections, particularly those in healthcare settings.
Not a fit: Patients who do not have a history of C. difficile infections or are not at risk for such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for C. difficile infections, reducing the burden of antibiotic-associated diarrhea.
How similar studies have performed: While the specific role of SASPs in C. difficile is not well-studied, similar approaches in other bacteria have shown promise in understanding spore resistance mechanisms.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SORG, JOE — TEXAS A&M UNIVERSITY
- Study coordinator: SORG, JOE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.