Understanding how bystander T cells can help fight tumors
Profiling and leveraging bystander T cells within the tumor microenvironment
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-11004714
This study is looking at how certain immune cells, called bystander T cells, can be activated to help fight cancer more effectively, which could lead to better treatments for patients with tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11004714 on ClinicalTrials.gov |
What this research studies
This research investigates the role of bystander T cells within the tumor microenvironment, which are often present in larger numbers than tumor-specific T cells. The study aims to understand how these bystander T cells can be activated and utilized to enhance anti-tumor immune responses. By employing various animal models, the research will explore the mechanisms that allow these T cells to enter tumors and their potential to respond to stimulation. This could lead to new strategies for improving cancer immunotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors who may benefit from enhanced immunotherapy approaches.
Not a fit: Patients with non-solid tumors or those who do not have a sufficient immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by harnessing the power of bystander T cells.
How similar studies have performed: Other research has shown promise in utilizing bystander T cells in cancer treatment, suggesting that this approach could be a valuable addition to existing therapies.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAURICE, NICHOLAS JOSEPH — UNIVERSITY OF MINNESOTA
- Study coordinator: MAURICE, NICHOLAS JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.