Understanding how BubR1 protein stability affects aging and stress responses
Official title: Regulatory Mechanisms Governing BubR1 Protein Stability During Stress and Aging
Funded at Creighton University · NIH-11085146 · Data updated 2026-11-12
This study is looking at how a protein called BubR1 changes as we get older and how this might be linked to age-related diseases like cancer, with the goal of finding ways to keep BubR1 levels stable to help improve health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | June 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $292,310 |
| NIH project number | 5R01AG077574-04 |
| Project ID | NIH-11085146 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues or those at risk for age-associated diseases.
✕Less likely to help
Patients who are younger and do not exhibit signs of accelerated aging or related health conditions may not benefit from this research.
What this research studies
This research investigates the role of the BubR1 protein in regulating aging and its connection to age-related diseases like cancer. It focuses on how BubR1 levels decline with age and how this decline is influenced by cellular stress and the activity of specific enzymes. By exploring the mechanisms behind BubR1 degradation, particularly through the action of E3 ubiquitin ligases, the research aims to uncover potential therapeutic targets that could enhance BubR1 stability and improve health outcomes related to aging.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing age-related diseases and improving longevity.
How similar studies have gone: Other research has shown promising results in targeting protein stability mechanisms to combat age-related decline, suggesting this approach may be effective.
Where this research is happening
-
Creighton University
Omaha, United States Active
Researchers
- Principal investigator: North, Brian J. — Creighton University
- Study coordinator: North, Brian J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.