Understanding how BRWD1 influences B cell development and immune response
Official title: The role of BRWD1 to establish epigenetic states for germinal center initiation, maintenance, and exit
Funded at University of Chicago · NIH-11014965 · Data updated 2026-11-12
This study is looking at a protein called BRWD1 to see how it helps B cells, which are important for our immune system, grow and work properly, and the findings could help us understand better how B cells behave in autoimmune diseases and other immune-related issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AI174324-03 |
| Project ID | NIH-11014965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with autoimmune disorders or those with compromised immune responses.
✕Less likely to help
Patients with conditions unrelated to B cell function or those not experiencing immune system issues may not receive benefit from this research.
What this research studies
This research investigates the role of a protein called BRWD1 in the development and function of B cells, which are crucial for the immune system. By studying genetically modified mice, the researchers aim to understand how BRWD1 affects the ability of B cells to form germinal centers, where they mature and produce antibodies. The study focuses on the different subpopulations of B cells and how their epigenetic states influence their function and differentiation. Patients may benefit from insights gained about B cell responses in autoimmune diseases and other conditions related to immune function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses or treating autoimmune diseases by targeting B cell differentiation.
How similar studies have gone: Other research has shown promising results in understanding B cell differentiation and function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Wright, Nathaniel Edwin — University of Chicago
- Study coordinator: Wright, Nathaniel Edwin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.