Understanding how Bruton's Tyrosine Kinase interacts with cell membranes
Official title: Molecular mechanism of membrane association of Bruton's Tyrosine Kinase
Funded at Yale University · NIH-10833475 · Data updated 2026-11-12
This study is looking at how a protein called Bruton's Tyrosine Kinase (Btk) works in B cells, which are important for your immune system, to help find better treatments for B cell cancers that might have fewer side effects.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $47,044 |
| NIH project number | 5F31CA278383-02 |
| Project ID | NIH-10833475 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with B cell malignancies, such as chronic lymphocytic leukemia or non-Hodgkin's lymphoma.
✕Less likely to help
Patients with non-B cell malignancies or those not affected by B cell-related disorders may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms by which Bruton's Tyrosine Kinase (Btk) associates with cell membranes, particularly in the context of B cell activation and proliferation. The study focuses on how the B cell receptor pathway triggers the production of signaling lipids that facilitate Btk's activation. By exploring alternative inhibitory sites on Btk, the research aims to develop more effective treatments for B cell malignancies, potentially reducing side effects associated with current therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with B cell malignancies, offering more targeted treatment options with fewer side effects.
How similar studies have gone: Previous research has shown success with Btk inhibitors in treating B cell malignancies, indicating a promising avenue for further exploration.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Mcallister, Rachel — Yale University
- Study coordinator: Mcallister, Rachel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.