Understanding how Bruton's Tyrosine Kinase interacts with cell membranes
Molecular mechanism of membrane association of Bruton's Tyrosine Kinase
['FUNDING_FELLOWSHIP'] · YALE UNIVERSITY · NIH-10833475
This study is looking at how a protein called Bruton's Tyrosine Kinase (Btk) works in B cells, which are important for your immune system, to help find better treatments for B cell cancers that might have fewer side effects.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10833475 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms by which Bruton's Tyrosine Kinase (Btk) associates with cell membranes, particularly in the context of B cell activation and proliferation. The study focuses on how the B cell receptor pathway triggers the production of signaling lipids that facilitate Btk's activation. By exploring alternative inhibitory sites on Btk, the research aims to develop more effective treatments for B cell malignancies, potentially reducing side effects associated with current therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with B cell malignancies, such as chronic lymphocytic leukemia or non-Hodgkin's lymphoma.
Not a fit: Patients with non-B cell malignancies or those not affected by B cell-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with B cell malignancies, offering more targeted treatment options with fewer side effects.
How similar studies have performed: Previous research has shown success with Btk inhibitors in treating B cell malignancies, indicating a promising avenue for further exploration.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCALLISTER, RACHEL — YALE UNIVERSITY
- Study coordinator: MCALLISTER, RACHEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.