Understanding how Brucella abortus survives stress and causes infection
Official title: Regulation of the Brucella abortus general stress response
Funded at Michigan State University · NIH-11097365 · Data updated 2026-11-12
This study is looking at how the Brucella abortus bacteria manage to survive tough conditions and cause long-lasting infections in animals, with the hope of finding new ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $489,590 |
| NIH project number | 5R01AI177619-02 |
| Project ID | NIH-11097365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of or currently suffering from brucellosis or related infections.
✕Less likely to help
Patients with infections caused by bacteria that do not share similar stress response mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the bacterium Brucella abortus adapts to stressful conditions and establishes chronic infections in mammals. By focusing on a specific signaling system that helps the bacteria respond to environmental stress, the study aims to identify key genes and proteins involved in this process. The researchers will conduct biochemical and genetic experiments to explore how these factors contribute to the bacterium's ability to survive and infect hosts. This work could lead to new strategies for treating infections caused by this pathogen.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments for brucellosis and other infections caused by similar bacteria.
How similar studies have gone: Previous research has shown success in understanding bacterial stress responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Crosson, Sean — Michigan State University
- Study coordinator: Crosson, Sean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.