Understanding how Brucella abortus survives stress and causes infection
Regulation of the Brucella abortus general stress response
['FUNDING_R01'] · MICHIGAN STATE UNIVERSITY · NIH-11097365
This study is looking at how the Brucella abortus bacteria manage to survive tough conditions and cause long-lasting infections in animals, with the hope of finding new ways to treat these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-11097365 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the bacterium Brucella abortus adapts to stressful conditions and establishes chronic infections in mammals. By focusing on a specific signaling system that helps the bacteria respond to environmental stress, the study aims to identify key genes and proteins involved in this process. The researchers will conduct biochemical and genetic experiments to explore how these factors contribute to the bacterium's ability to survive and infect hosts. This work could lead to new strategies for treating infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently suffering from brucellosis or related infections.
Not a fit: Patients with infections caused by bacteria that do not share similar stress response mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments for brucellosis and other infections caused by similar bacteria.
How similar studies have performed: Previous research has shown success in understanding bacterial stress responses, suggesting that this approach could yield valuable insights.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CROSSON, SEAN — MICHIGAN STATE UNIVERSITY
- Study coordinator: CROSSON, SEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.