Understanding how brown fat can reduce inflammation and help treat metabolic disorders
Mechanistic characterization of the anti-inflammatory function of thermogenic fat for the treatment of metabolic disorders
This study is looking at how certain types of fat in your body, called brown and beige fat, can help fight inflammation and improve health issues related to obesity, like type-2 diabetes and heart disease, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10789849 on NIH RePORTER |
What this research studies
This research investigates the role of thermogenic fat, specifically brown and beige adipose tissue, in combating obesity-related inflammation and metabolic disorders. The study aims to identify the mechanisms by which these types of fat can help reduce inflammation and improve metabolic health. By examining how thermogenic fat interacts with various signals in the body, the research seeks to uncover potential therapeutic targets for conditions like type-2 diabetes and cardiovascular diseases. Patients may benefit from insights that could lead to new treatments aimed at enhancing the function of this beneficial fat.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or related metabolic disorders, such as type-2 diabetes or cardiovascular diseases.
Not a fit: Patients who do not have obesity or related metabolic disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that harness the anti-inflammatory properties of brown fat to improve metabolic health.
How similar studies have performed: Other research has shown promising results in understanding the role of brown fat in metabolism, suggesting that this approach has potential for significant breakthroughs.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Mills, Evanna Louisa — Dana-Farber Cancer Inst
- Study coordinator: Mills, Evanna Louisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.