Understanding how breast fat cells change during breastfeeding and after weaning
Mammary Adipocyte Remodeling in Health and Disease
This study is looking at how breast fat cells change during breastfeeding and after stopping, to help moms with obesity and type 2 diabetes produce enough milk and improve their health and their babies' health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10799659 on NIH RePORTER |
What this research studies
This research investigates the complex changes that occur in breast fat cells during breastfeeding and after weaning. It aims to understand how these fat cells can transform into precursor-like cells and then revert back to their original state, which is crucial for successful lactation. By studying these processes, the research seeks to address issues related to insufficient milk production in mothers with obesity and type 2 diabetes. The findings could help improve lactation outcomes and reduce the risk of metabolic disorders in both mothers and their children.
Who could benefit from this research
Good fit: Ideal candidates for this research include mothers who are experiencing difficulties with milk production, particularly those with obesity or type 2 diabetes.
Not a fit: Patients who are not mothers or who do not have issues related to breastfeeding or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved breastfeeding outcomes for mothers with obesity and type 2 diabetes, ultimately benefiting their children's health.
How similar studies have performed: Previous research has shown promising results in understanding cellular remodeling in other contexts, but this specific approach to mammary adipocyte remodeling is relatively novel.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Wang, Qiong Annabel — Beckman Research Institute/city of Hope
- Study coordinator: Wang, Qiong Annabel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.